BDBM50593291 CHEMBL5169819

SMILES Cc1cnc(Nc2cccc(c2)S(N)(=O)=O)nc1Nc1ccc2oc(=O)[nH]c2c1

InChI Key InChIKey=QGKQWTDGYMKJSW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50593291   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593291(CHEMBL5169819)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of SYK (unknown origin) assessed as reduction of IgM-stimulated ERK phosphorylation by Cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593291(CHEMBL5169819)
Affinity DataIC50:  34nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed