BDBM50594147 CHEMBL5203091

SMILES CCN(C1CCC(F)(F)CC1)c1cc(O[C@H]2C[C@@H](C2)N2CCCCC2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C

InChI Key InChIKey=QORWWAYMVGOJGG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50594147   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 0.600nMAssay Description:Table 1: Test ConditionsEZH2 enzyme complex: 25 ng/uLHistone H3 peptide substrate: 4 uMSAM: 2 uMReaction time: 300 minProcedures1. Each compound disc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 1nMAssay Description:ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of DMSO was 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50594147(CHEMBL5203091 | US12390472, Example 68)
Affinity DataIC50: 1.10nMAssay Description:Table 4: ProceduresCompounds at different concentrations were dissolved in 100% DMSO and transferred to test plates, and the final concentration of D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent