BDBM50594591 CHEMBL5195764::US20260125365, Compound II-0015

SMILES Cc1cncc(c1)-n1c(=O)nc(Nc2cc3cn(C)nc3cc2Cl)n(Cc2cc(C#N)c(F)cc2C)c1=O

InChI Key InChIKey=RSRZUZBVBZKEKS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50594591   

TargetReplicase polyprotein 1a(2019-nCoV)
Shionogi & Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50594591BDBM50594591(CHEMBL5195764 | US20260125365, Compound II-0015)
Affinity DataIC50: 1.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2026
Entry Details
US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Experimental Drug Development Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594591BDBM50594591(CHEMBL5195764 | US20260125365, Compound II-0015)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant SARS-CoV-2 main protease usingDABCYLKTSAVLQSGFRKME(EDANS)-NH2 fluorogenic peptide substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Experimental Drug Development Centre

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594591BDBM50594591(CHEMBL5195764 | US20260125365, Compound II-0015)
Affinity DataIC50: 35nMAssay Description:Inhibition of SARS-CoV-2 3CLp by mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed