BDBM50595799 CHEMBL5186159

SMILES NS(=O)(=O)c1ccc(Nc2ncc3c(n2)N(C2CCCC2)C(=O)C32CC2)cc1

InChI Key InChIKey=AMDWMDLEIXAHBS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50595799   

LigandPNGBDBM50595799(CHEMBL5186159)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged full-length CDK2/Flag-tagged cyclinE1 expressed in baculovirus expression system using eIF4E-bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50595799(CHEMBL5186159)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of CDK2 in human COV318 cells incubated for overnight in presence of phospho-Rb by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50595799(CHEMBL5186159)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK1 in human OVCAR3 cells incubated for 30 mins in presence of pNPM T199 by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50595799(CHEMBL5186159)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of CDK2 in human COV318 cells incubated for overnight in presence of human whole blood by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed