BDBM50596243 CHEMBL5174392

SMILES CC1(C)C(=N)N[C@@](C)(CS1(=O)=O)c1nc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=LTYYZTCFGRCEBL-IBGZPJMESA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50596243   

TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataKi:  4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK cells by voltage clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataIC50:  1.59E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596243(CHEMBL5174392)
Affinity DataIC50:  1nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed