BDBM50596718 CHEMBL5184703::US12527775, Compound I-008::US20230348421, Compound 1

SMILES CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cn2)C2CCN(C)CC2)cc1

InChI Key InChIKey=MLLAVJGUUBZDGD-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50596718   

Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596718BDBM50596718(CHEMBL5184703 | US20230348421, Compound 1 | US1252...)
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596718BDBM50596718(CHEMBL5184703 | US20230348421, Compound 1 | US1252...)
Affinity DataIC50: 8.64nMAssay Description:CHO-K1/5-HT2A cells in the logarithmic growth phase were seeded into a 384-well plate at a density of 10000 cells per well, and cultured in a 37° C.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596718BDBM50596718(CHEMBL5184703 | US20230348421, Compound 1 | US1252...)
Affinity DataKi: <10nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute, TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2026
Entry Details Article
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Shionogi

US Patent
LigandChemical structure of BindingDB Monomer ID 50596718BDBM50596718(CHEMBL5184703 | US20230348421, Compound 1 | US1252...)
Affinity DataKi: <10nMAssay Description:In advance, 0.5 μL of the compound solution dissolved in DMSO was dispensed into a microplate, and the cell membrane and the hot ligand were diluted ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2026
Entry Details Article
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596718BDBM50596718(CHEMBL5184703 | US20230348421, Compound 1 | US1252...)
Affinity DataIC50: 22.8nMAssay Description:NIH3T3-5HT2AR cells in the logarithmic growth phase were seeded into a white-wall clear-bottom 96-well plate at a density of 1000 cells per well, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596718BDBM50596718(CHEMBL5184703 | US20230348421, Compound 1 | US1252...)
Affinity DataIC50: 23nMAssay Description:Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Geneora Pharma (Shijiazhuang) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50596718BDBM50596718(CHEMBL5184703 | US20230348421, Compound 1 | US1252...)
Affinity DataIC50: 410nMAssay Description:CHO (Chinese Hamster Ovary) cells stably expressing hERG potassium channels were taken, and hERG potassium channel currents were recorded at room tem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent