BDBM50597103 CHEMBL5199127::US20230287003, Example 6a

SMILES C[C@H]1COC(=O)c2c(N1)c1cc(Nc3ccnc(Cl)c3C#N)ccc1n(C)c2=O

InChI Key InChIKey=HECAYGOIQMGZQS-JTQLQIEISA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50597103   

TargetB-cell lymphoma 6 protein(Homo sapiens)
Cancer Research Technology

US Patent
LigandPNGBDBM50597103(CHEMBL5199127 | US20230287003, Example 6a)
Affinity DataIC50:  97.7nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
Cancer Research Technology

US Patent
LigandPNGBDBM50597103(CHEMBL5199127 | US20230287003, Example 6a)
Affinity DataIC50:  94nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
Cancer Research Technology

US Patent
LigandPNGBDBM50597103(CHEMBL5199127 | US20230287003, Example 6a)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human C-terminal nanoLuc-tagged BCL6 expressed in HEK293T cells co-expressing HaloTagged-SMRT using NanoBRET furimazine as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB