BDBM50597182 CHEMBL5181966

SMILES Cc1[nH]nc(c1-c1ccc(-c2cccc(c2)S(N)(=O)=O)c(c1)C1CC1)-c1ccnc(C)c1

InChI Key InChIKey=LWAOLQIWVBZQLW-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50597182   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50597182(CHEMBL5181966)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of full-length LRRK2 G2019S mutant (unknown origin) using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-FRET based ADA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50597182(CHEMBL5181966)
Affinity DataIC50: 17nMAssay Description:Inhibition of full-length wild type LRRK2 (unknown origin) using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-FRET based ADAPTA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Mouse)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50597182(CHEMBL5181966)
Affinity DataEC50:  280nMAssay Description:Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells using LRRKtide as substrate in presence of ATP by incubated for 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Mouse)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50597182(CHEMBL5181966)
Affinity DataEC50:  5.40E+3nMAssay Description:Inhibition of mouse full-length wild type LRRK2 transfected in HEK293 cells using LRRKtide as substrate incubated for 1 hr in presence of ATP by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed