BDBM50597491 CHEMBL5201650

SMILES COc1cccc([C@@H](C)NC(=O)N2CCN(C[C@H]2C)c2ccncc2F)c1F

InChI Key InChIKey=TXNKTKFDGSSTCB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50597491   

TargetRho-associated protein kinase 2(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597491(CHEMBL5201650)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50597491(CHEMBL5201650)
Affinity DataIC50: 5.09E+4nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged human PKG expressed in baculovirus infected Sf9 insect cells using RSK as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed