BDBM50598259 CHEMBL5194529

SMILES COc1ccccc1CN1C2=NCCN2C2=C(CN(Cc3ccc(cc3)C(=O)Nc3ccccc3N)CC2)C1=O

InChI Key InChIKey=JRYSTMMUZUGAAW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50598259   

TargetHistone deacetylase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598259(CHEMBL5194529)
Affinity DataIC50: 156nMAssay Description:Inhibition of human HDAC1 using RHKKAc fluorogenic peptide as substrate preincubated for 10 mins followed by substrate addition by fluorescence based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598259(CHEMBL5194529)
Affinity DataIC50: 346nMAssay Description:Inhibition of human HDAC2 using RHKKAc fluorogenic peptide as substrate preincubated for 10 mins followed by substrate addition by fluorescence based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598259(CHEMBL5194529)
Affinity DataIC50: 589nMAssay Description:Inhibition of human HDAC3/NcoR2 using RHKKAc fluorogenic peptide as substrate preincubated for 10 mins followed by substrate addition by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598259(CHEMBL5194529)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598259(CHEMBL5194529)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HDAC11 using Boc-Lys(trifluoroacetyl)-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate addition by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598259(CHEMBL5194529)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HDAC8 using RHKAcKAc as fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluorescence based analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed