BDBM50598490 CHEMBL5202032

SMILES CC(C)N1CCc2cc(Nc3cc4cc(c(F)cc4cn3)-c3cncc(N)c3C)nn2CC1=O

InChI Key InChIKey=CETQDVWYQQVKEU-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50598490   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598490(CHEMBL5202032 | US12378249, Compound 119)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of full-length HPK1 (unknown origin) assessed as inhibition constant in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598490(CHEMBL5202032 | US12378249, Compound 119)
Affinity DataKi:  0.0500nMAssay Description:Assay Condition:The following assay concentrations and times were used: 2 nM HPK1, 2 nM Eu-Anti-GST Ab, and 15 nM Tracer222, with 60 min incubation t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2025
Entry Details
US Patent