BDBM50598663 CHEMBL5209276

SMILES CNC(=O)c1cnc(Nc2ccnc(n2)N2CCC(O)CC2)cc1NC(C)C

InChI Key InChIKey=LRIWJFVDBQRHIK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50598663   

TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598663(CHEMBL5209276)
Affinity DataIC50: 266nMAssay Description:Inhibition of wild type EGFR L858R/T790M/C797S triple mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598663(CHEMBL5209276)
Affinity DataIC50: 290nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598663(CHEMBL5209276)
Affinity DataIC50: 914nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598663(CHEMBL5209276)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598663(CHEMBL5209276)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged recombinant wild type human EGFR expressed in baculovirus infected Sf9 insect cells expression system using 5-FAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50598663(CHEMBL5209276)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of wild type EGFR in human A-431 cells preincubated for 4 to 5 hrs followed by EGF stimulation for 10 mins by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed