BDBM50598700 CHEMBL5194472

SMILES COc1cc(OC)cc(c1)[C@@H](C)C(=O)N1CC[C@]2(C1)CCc1cc(-c3cnn(C)c3)c(C)nc1N2

InChI Key InChIKey=VPLWSGGNMOIHSS-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50598700   

TargetMelanocortin receptor 4(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50598700(CHEMBL5194472 | US20250084084, Example 91)
Affinity DataKi:  0.0440nMAssay Description:Displacement of [125I]-[Nle4-D-phe7]-alpha-MSH from to human MC4R expressed in CHO cells incubated for 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50598700(CHEMBL5194472 | US20250084084, Example 91)
Affinity DataKi:  0.0440nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50598700(CHEMBL5194472 | US20250084084, Example 91)
Affinity DataKi:  0.0440nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50598700(CHEMBL5194472 | US20250084084, Example 91)
Affinity DataKi:  17nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50598700(CHEMBL5194472 | US20250084084, Example 91)
Affinity DataKi:  17nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent