BDBM50599030 CHEMBL5182180::US20230322715, Compound TR-FTO-45

SMILES Fc1ccc2[nH]cc(CNCC3(N4CCC(F)C4)COC3)c2c1

InChI Key InChIKey=RNHPSRLXONDBGQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50599030   

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 50599030BDBM50599030(CHEMBL5182180 | US20230322715, Compound TR-FTO-45)
Affinity DataIC50: 900nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 50599030BDBM50599030(CHEMBL5182180 | US20230322715, Compound TR-FTO-45)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 50599030BDBM50599030(CHEMBL5182180 | US20230322715, Compound TR-FTO-45)
Affinity DataIC50: 3.05E+4nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetRNA demethylase ALKBH5(Human)
University of California

US Patent
LigandChemical structure of BindingDB Monomer ID 50599030BDBM50599030(CHEMBL5182180 | US20230322715, Compound TR-FTO-45)
Affinity DataIC50: 3.05E+4nMAssay Description:Inhibition of ALKBH5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed