BDBM50599226 CHEMBL5201062::US11866405, Example 100

SMILES CO[C@H]1C[C@@H](C1)Oc1cc2nn(cc2cc1C(=O)Nc1cnc2cccnn12)C1CCC2(CN(C2)C(C)=O)CC1

InChI Key InChIKey=FKRCXWXNDQEWLF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50599226   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50599226(CHEMBL5201062 | US11866405, Example 100)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus infected insect cells using KKARFSRFAGSSPSQSSMVAR as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50599226(CHEMBL5201062 | US11866405, Example 100)
Affinity DataIC50: 0.0300nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent