BDBM50601063 CHEMBL5202863::US11702418, Example 1-13

SMILES COc1cc2cnnc(N[C@H](C)c3cccc(c3C)C(F)(F)F)c2cc1OC

InChI Key InChIKey=FZGCUSRTDSOYLS-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50601063   

LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataKi:  13nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataKi:  13nMAssay Description:Binding affinity to human recombinant SOS1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataKi:  13nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1 [564-1049](Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataIC50: 31nMAssay Description:Table 21: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049](Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataIC50: 378nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50601063(CHEMBL5202863 | US11702418, Example 1-13)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR in presence of ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed