BDBM50601091 CHEMBL5171096::US11702418, Example 4-1

SMILES COc1cc2c(C)nnc(N[C@H](C)c3cccc(c3C)C(F)(F)F)c2cc1OC

InChI Key InChIKey=SUSQYYGPLOUGJB-GFCCVEGCSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50601091   

TargetSon of sevenless homolog 1(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50601091(CHEMBL5171096 | US11702418, Example 4-1)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM50601091(CHEMBL5171096 | US11702418, Example 4-1)
Affinity DataIC50:  6.5nMAssay Description:Table 21: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM50601091(CHEMBL5171096 | US11702418, Example 4-1)
Affinity DataIC50:  327nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair
In DepthDetails US Patent