BDBM50603600 CHEMBL5197602

SMILES S=c1[nH]nc(o1)-c1ccc2[nH]c(nc2c1)-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=JNVAVIXHRVMILI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50603600   

TargetProstaglandin E synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603600(CHEMBL5197602)
Affinity DataIC50: 30nMAssay Description:Inhibition of mPGES-1 activity in human A549 microsomal preparation using PGH2 as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetLeukotriene C4 synthase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603600(CHEMBL5197602)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human recombinant LTC4S expressed in HEK293 cell microsomal fraction preincubated for 10 mins followed by LTA4-methyl ester addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM50603600(CHEMBL5197602)
Affinity DataIC50: 3.71E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as inhibition of FLAP-dependent 5-LO product LTB4 formation preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed