BDBM50604027 CHEMBL5184634::US20230312529, Compound 6i

SMILES CCN1CCN(c2ccc(Nc3ncc(C)c(Nc4ccc5cn[nH]c5c4)n3)cc2OC)CC1

InChI Key InChIKey=PQIKUMYNSRASMV-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50604027   

TargetPlatelet-derived growth factor receptor beta(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 1.70nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 1.70nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 2.70nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 2.70nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Wenzhou Medical University

US Patent
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 5nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Wenzhou Medical University

US Patent
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 7.70nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Wenzhou Medical University

US Patent
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 27nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Wenzhou Medical University

US Patent
LigandChemical structure of BindingDB Monomer ID 50604027BDBM50604027(CHEMBL5184634 | US20230312529, Compound 6i)
Affinity DataIC50: 694nMAssay Description:The method adopted in the test was Caliper Mobility Shift Assay, which was a detection platform based on the mobility detection technology of microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent