BDBM50604141 CHEMBL5188433

SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(Cl)c1

InChI Key InChIKey=PFMMJDPMFCVRCB-IBGZPJMESA-N

Data  1 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50604141   

TargetAP2-associated protein kinase 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataKi:  0.110nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of full length human AAK1 expressed in HEK293F cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetBMP-2-inducible protein kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  6nMAssay Description:Inhibition of BIKE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  1.86E+3nMAssay Description:Inhibition of MAP2K1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDual specificity protein kinase CLK4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  740nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetNuclear receptor subfamily 2 group C member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  120nMAssay Description:Inhibition of TAK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed