BDBM50604442 CHEMBL5191715

SMILES COc1c(cnc2ccccc12)\N=N\c1cccc(c1)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F

InChI Key InChIKey=YIQCWOGLRHLGOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50604442   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50604442(CHEMBL5191715)
Affinity DataIC50: 24nMAssay Description:Inhibition of human RET kinase using IGF1Rtide as substrate incubated for 40 mins and measured by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Gothenburg

Curated by ChEMBL
LigandPNGBDBM50604442(CHEMBL5191715)
Affinity DataIC50: 920nMAssay Description:Inhibition of full-length RET kinase expressed in human HEK293 cells and measured by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed