BDBM506055 6-(((SHH(1S,2S)-2- fluorocyclopropyl)-1H-1,2,3- triazol-4-yl)(isoquinolin-5- yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile::US11066414, Compound 704

SMILES CC(C)(C)CNc1c(C#N)cnc2c(C#N)cc(N[C@H](C3=CN(C4C[C@@H]4F)NN3)c3cccc4cnccc34)cc12

InChI Key InChIKey=VVWRBRKNGYZLSA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 506055   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 506055BDBM506055(6-(((SHH(1S,2S)-2- fluorocyclopropyl)-1H-1,2,3- tr...)
Affinity DataIC50: 1nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
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Date in BDB:
12/23/2021
Entry Details
US Patent