BDBM50606339 CHEMBL5175305::US12617784, Example 9

SMILES CC(C)NC[C@@H](C(=O)N1CCN(C[C@@H]1C)c1ncnc2NC(=O)C[C@@H](C)c12)c1ccc(Cl)cc1

InChI Key InChIKey=JNHNQKIFPQKEFS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50606339   

TargetRAC-gamma serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50606339BDBM50606339(CHEMBL5175305 | US12617784, Example 9)
Affinity DataIC50: 3.30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-gamma serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50606339BDBM50606339(CHEMBL5175305 | US12617784, Example 9)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant N-terminal GST tagged AKT2 (108 to 479 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50606339BDBM50606339(CHEMBL5175305 | US12617784, Example 9)
Affinity DataIC50: 167nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-beta serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50606339BDBM50606339(CHEMBL5175305 | US12617784, Example 9)
Affinity DataIC50: 206nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50606339BDBM50606339(CHEMBL5175305 | US12617784, Example 9)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant AKT1 (104 to 480 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptide substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50606339BDBM50606339(CHEMBL5175305 | US12617784, Example 9)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant AKT2 (120 to 481 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptide substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed