BDBM50607250 CHEMBL5219146

SMILES NCc1cccc(c1)-n1nc(cc1C(=O)Nc1cc(ccc1F)C(O)(CCC1CC1)c1ccncc1)C(F)(F)F

InChI Key InChIKey=BHLLHZZJYJWRRD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50607250   

TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50607250(CHEMBL5219146)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of purified human plasma kallikrein using H-D-Pro-Phe-Arg-pNA.2HCl as substrate measured after 3 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50607250(CHEMBL5219146)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of purified human plasma kallikrein using H-D-Pro-Phe-Arg-pNA.2HCl as substrate measured after 3 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50607250(CHEMBL5219146)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of endogenous human plasma kallikrein using Z-Phe-Arg-AMC.HCl as substrate measured after 5 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50607250(CHEMBL5219146)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of endogenous human plasma kallikrein using Z-Phe-Arg-AMC.HCl as substrate measured after 5 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed