BDBM50609476 CHEMBL5274631

SMILES [H][C@@]12COc3cc4nc(C)nc(N[C@H](C)c5cccc(C(F)F)c5F)c4cc3N1CCN(C2)C(=O)[C@H]1CCOC1

InChI Key InChIKey=HGHGNXYWUVTGMS-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50609476   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells clamped at -80 mV stimulated +20 mV for 2 sec followed by repolarized to -50 mV for 5 secs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsome suspension using diclofenac substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsome suspension using dextromethorphan substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsome suspension using amodiaquine substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsome suspension using midazolam substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsome suspension using omeprazole substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Wuhan University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50609476(CHEMBL5274631)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsome suspension using phenacetin substrate incubated for 30 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed