BDBM50609713 CHEMBL5269792

SMILES [H][C@]12CN(c3nc(cc(n3)-c3cnc(N)c(OC(F)F)n3)[C@H]3CCCO3)[C@]([H])(CO1)C2

InChI Key InChIKey=AKKHHVJIISFQCL-PKFCDNJMSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50609713   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609713(CHEMBL5269792)
Affinity DataEC50:  77nMAssay Description:Inhibition of human DLK expressed in HEK cells assessed as reduction in phospho-c-Jun level preincubated for 45 mins followed by doxycycline stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609713(CHEMBL5269792)
Affinity DataIC50:  202nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human LZK (9 to 114 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609713(CHEMBL5269792)
Affinity DataIC50:  61nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DLK (9 to 111 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed