BDBM50609716 CHEMBL5272522

SMILES CCOC(=O)N1C[C@@H]2C[C@H]1CN2c1nc(-c2cnc(N)c(OC(F)F)n2)cc(N2CC3CC2C3)n1

InChI Key InChIKey=JKALQBFVHDTVCS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50609716   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50609716BDBM50609716(CHEMBL5272522)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DLK (9 to 111 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Human)
Denali Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50609716BDBM50609716(CHEMBL5272522)
Affinity DataEC50:  4nMAssay Description:Inhibition of human DLK expressed in HEK cells assessed as reduction in phospho-c-Jun level preincubated for 45 mins followed by doxycycline stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50609716BDBM50609716(CHEMBL5272522)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human LZK (9 to 114 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed