BDBM50612188 CHEMBL5283628

SMILES CN1CCC(CC1)n1cc(Nc2nc(OC3(C)CC3)c3nc(ccc3n2)-c2cncnc2)cn1

InChI Key InChIKey=QQIQOMIKWUAMAA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50612188   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  24nMAssay Description:Inhibition of IRAK4 (unknown origin) phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK1 (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  44nMAssay Description:Inhibition of BTK (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNT-3 growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  36nMAssay Description:Inhibition of TRKC (unknown origin) in presence of 50 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  18nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of 75 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  19nMAssay Description:Inhibition of TRKA (unknown origin) in presence of 400 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  82nMAssay Description:Inhibition of TRKB (unknown origin) in presence of 25 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50612188(CHEMBL5283628)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of 600 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed