BDBM50613689 CHEMBL5281446

SMILES CC(C)c1nn(C(C)C)c2cc(Nc3ccnc(n3)-c3cnn(c3)S(=O)(=O)C3CC3)ncc12

InChI Key InChIKey=WGQWOAUHLRBBJE-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50613689   

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613689(CHEMBL5281446)
Affinity DataKi:  24nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613689(CHEMBL5281446)
Affinity DataKi: <531nMAssay Description:Inhibition of wild type human EGFR assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613689(CHEMBL5281446)
Affinity DataIC50: 910nMAssay Description:Inhibition of EGFR T790M/del (746 to 750 residues) mutant autophosphorylation in human PC-9/ER1 cells harboring harboring EGFR T790M/del (746 to 750 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613689(CHEMBL5281446)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells harboring harboring EGFR L858R/T790M double mutant preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613689(CHEMBL5281446)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of EGFR del (746 to 750) mutant autophosphorylation in human PC-9 cells harboring harboring EGFR del (746 to 750) mutant preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613689(CHEMBL5281446)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR autophosphorylation in human NCI-H292 cells harboring harboring wild type EGFR preincubated for 60 mins followed by EGF stimulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed