BDBM50613692 CHEMBL5277269

SMILES CC(C)n1c(C)nc2cnc(Nc3ccnc(n3)-c3cnn(c3)S(C)(=O)=O)cc12

InChI Key InChIKey=NIIMEGBHZANHEE-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50613692   

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613692(CHEMBL5277269)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human EGFR T790M/del (746 to 750 residues) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613692(CHEMBL5277269)
Affinity DataKi:  18nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613692(CHEMBL5277269)
Affinity DataKi:  38nMAssay Description:Inhibition of human EGFR del (746 to 750) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613692(CHEMBL5277269)
Affinity DataKi:  126nMAssay Description:Inhibition of human EGFR L858R mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613692(CHEMBL5277269)
Affinity DataKi:  324nMAssay Description:Inhibition of wild type human EGFR assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed