BDBM50613693 CHEMBL5281373

SMILES CC(C)n1c(C)nc2cnc(Nc3ccnc(n3)-c3cnn(c3)S(=O)(=O)C3CC3)cc12

InChI Key InChIKey=NOWVRPHFPYFSDG-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50613693   

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613693(CHEMBL5281373)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human EGFR T790M/del (746 to 750 residues) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613693(CHEMBL5281373)
Affinity DataKi:  4.10nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613693(CHEMBL5281373)
Affinity DataKi:  12nMAssay Description:Inhibition of human EGFR del (746 to 750) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613693(CHEMBL5281373)
Affinity DataKi:  43nMAssay Description:Inhibition of human EGFR L858R mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50613693(CHEMBL5281373)
Affinity DataKi:  55nMAssay Description:Inhibition of wild type human EGFR assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)