BDBM50614150 CHEMBL5277470

SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)C(=C\c3ccccc3)\C#N)nc2n(C2CCCC2)c1=O

InChI Key InChIKey=MCGRCAVMPSXODJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50614150   

TargetCyclin-dependent kinase 6(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50614150(CHEMBL5277470)
Affinity DataIC50: 19nMAssay Description:Covalent inhibition of CDK6 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50614150(CHEMBL5277470)
Affinity DataIC50: 25nMAssay Description:Covalent inhibition of CDK4 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50614150(CHEMBL5277470)
Affinity DataIC50: 1.00E+3nMAssay Description:Covalent inhibition of CDK9 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50614150(CHEMBL5277470)
Affinity DataIC50: 1.00E+3nMAssay Description:Covalent inhibition of CDK12 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed