BDBM50614182 CHEMBL5291403

SMILES Nc1ncnc2n(cc(-c3cnc4ccccc4c3)c12)[C@@H]1CCN(C1)C(=O)C=C

InChI Key InChIKey=IQJPWAAWPFBLPZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50614182   

TargetEpidermal growth factor receptor(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50614182(CHEMBL5291403)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human EGFR del19/T790M using biotinEEPLYWSFPAKKK-NH2 as substrate incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50614182(CHEMBL5291403)
Affinity DataIC50: 313nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed