BDBM50614301 CHEMBL5270382

SMILES Nc1nccc(Nc2cc(F)c(Oc3ccnc4[nH]cc(C#N)c34)c(F)c2)n1

InChI Key InChIKey=IGSCJRALLFHGQF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50614301   

TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50614301(CHEMBL5270382)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of His-tagged human ROCK2 expressed in Sf9 cells pre-incubated for 10 mins before S6 peptide substrate addition in presence of [33P]ATP an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bayer HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50614301(CHEMBL5270382)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed