BDBM50614740 CHEMBL5281778

SMILES CC1=CC(C)=[N+]2C1=C(c1nc(C)cn1[B-]2(F)F)c1ccc(OCCn2cc(CCCCOc3cc(nc4c(C)c5nc(cc(O)c5cc34)C(O)=O)C(O)=O)nn2)cc1

InChI Key InChIKey=OZMINXGQAXYZSF-UHFFFAOYSA-N

Data  2 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50614740   

TargetG-protein coupled receptor 35(Human)
Dalian Institute of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50614740(CHEMBL5281778)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to Nluc-fused human GPR35 expressed in CHO-K1 cells using furimazine as substrate incubated for 30 mins in presence of zaprinast fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG-protein coupled receptor 35(Human)
Dalian Institute of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50614740(CHEMBL5281778)
Affinity DataIC50: 9.40nMAssay Description:Agonist activity at GPR-35 in human HT-29 cells assessed as desensitization of zaprinast induced DMR response incubated for 1 hr followed by zaprinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG-protein coupled receptor 35(Human)
Dalian Institute of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50614740(CHEMBL5281778)
Affinity DataEC50:  50nMAssay Description:Agonist activity at GPR-35 in human HT-29 cells by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG-protein coupled receptor 35(Human)
Dalian Institute of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50614740(CHEMBL5281778)
Affinity DataIC50: 542nMAssay Description:Agonist activity at GPR-35 in human HT-29 cells assessed as desensitization of zaprinast induced DMR response incubated for 1 hr followed by zaprinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed