BDBM50615003 CHEMBL5278658::US20240109900, Example 79

SMILES Cc1csc([C@@]2(CN)[C@@H]3CCN(c4cnc5c(-c6ccc7nn(C)cc7c6Cl)n[nH]c5n4)C[C@@H]32)n1

InChI Key InChIKey=FIDXYKFRGLNFAF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50615003   

LigandChemical structure of BindingDB Monomer ID 50615003BDBM50615003(CHEMBL5278658 | US20240109900, Example 79)
Affinity DataIC50: 6nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50615003BDBM50615003(CHEMBL5278658 | US20240109900, Example 79)
Affinity DataIC50: 107nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50615003BDBM50615003(CHEMBL5278658 | US20240109900, Example 79)
Affinity DataIC50: 500nMAssay Description:Assay volume of 20 μL/well was assembled in 384 well black polystyrene low-binding microplates (Greiner), using the following buffer: 60 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent