BDBM50615015 CHEMBL5289856::US20240109900, Example 486

SMILES Cn1cc2c(Cl)c(-c3n[nH]c4nc(N5C[C@@H]6[C@H](C5)[C@@]6(CN)c5nccs5)cnc34)ccc2n1

InChI Key InChIKey=TXOKYWOCCYLWCA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50615015   

LigandChemical structure of BindingDB Monomer ID 50615015BDBM50615015(CHEMBL5289856 | US20240109900, Example 486)
Affinity DataIC50: 4nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50615015BDBM50615015(CHEMBL5289856 | US20240109900, Example 486)
Affinity DataIC50: 500nMAssay Description:Assay volume of 20 μL/well was assembled in 384 well black polystyrene low-binding microplates (Greiner), using the following buffer: 60 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50615015BDBM50615015(CHEMBL5289856 | US20240109900, Example 486)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed