BDBM50615016 CHEMBL5272403::US20240109900, Example 488

SMILES Cn1cc2c(Cl)c(-c3n[nH]c4nc(N5C[C@@H]6[C@H](C5)[C@@]6(CN)c5nc(Cl)cs5)cnc34)ccc2n1

InChI Key InChIKey=ASLHBKFCMSZPCE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50615016   

LigandChemical structure of BindingDB Monomer ID 50615016BDBM50615016(CHEMBL5272403 | US20240109900, Example 488)
Affinity DataIC50: 5nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50615016BDBM50615016(CHEMBL5272403 | US20240109900, Example 488)
Affinity DataIC50: 500nMAssay Description:Assay volume of 20 μL/well was assembled in 384 well black polystyrene low-binding microplates (Greiner), using the following buffer: 60 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50615016BDBM50615016(CHEMBL5272403 | US20240109900, Example 488)
Affinity DataIC50: 500nMAssay Description:Assay volume of 20 μL/well was assembled in 384 well black polystyrene low-binding microplates (Greiner), using the following buffer: 60 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50615016BDBM50615016(CHEMBL5272403 | US20240109900, Example 488)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed