BDBM50615046 CHEMBL5289001

SMILES CN1CCN(c2ccc(Nc3ncc4c(=O)n(-c5ccccc5F)n(-c5cccc(C(C)(C)O)n5)c4n3)cc2)CC1

InChI Key InChIKey=CYDYWAYVIILVQJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50615046   

TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615046BDBM50615046(CHEMBL5289001)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Emd Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615046BDBM50615046(CHEMBL5289001)
Affinity DataIC50: 160nMAssay Description:Inhibition of human N-terminal His6-tagged recombinant full-length PLK1 expressed in baculovirus infected Sf9 cells incubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615046BDBM50615046(CHEMBL5289001)
Affinity DataIC50: 230nMAssay Description:Inhibition of WEE1 in human U2OS cells incubated for 1 hr by mesoscale discovery assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed