BDBM50616998 CHEMBL5401297

SMILES FC(F)OC1CC(CCC1Cl)n1cc(COc2ncccc2F)nn1

InChI Key InChIKey=UZCFNRZJDCERJZ-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50616998   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50616998(CHEMBL5401297)
Affinity DataIC50: 130nMAssay Description:Negative allosteric modulation of human GluN1A/GluN2B receptor expressed in T-REX-CHO cells preincubated for 5 mins followed by glutamate and glycine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50616998(CHEMBL5401297)
Affinity DataKi:  889nMAssay Description:Displacement of 3-(3H) 1-(azetidin-1-yl)-2-(6- (4-fluoro-3-methyl-phenyl)pyrrolo-(3,2-6) pyridin-1yl)ethanone from GluN2B receptor in rat cortical me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50616998(CHEMBL5401297)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50616998(CHEMBL5401297)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50616998(CHEMBL5401297)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed