BDBM50617048 CHEMBL5432266

SMILES COc1cc([C@@H](C)C(=O)N2CC[C@]3(C2)COc2cc(c(C)nc2N3)-c2ncccn2)c(F)cn1

InChI Key InChIKey=GDRJSPPVRGELGB-UHFFFAOYSA-N

Data  6 KI  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50617048   

TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  0.460nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrs in presence of alpha-MSHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  0.460nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in CHO cells by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  0.520nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from rat MC4R expressed in CHO cells by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human MC4R in CHO cells measured for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  340nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in CHO cells measured for 2 hrs by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocortin receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi:  840nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in CHO cells measured for 2 hrs by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataKi: >1.60E+3nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in CHO cells measured for 2 hrs by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE1B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE2A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE5A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE3AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE4D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE9A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE10A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE7BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE8BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE11A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50617048(CHEMBL5432266)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human Nav1.5 expressed in CHO cells by whole cell voltage clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed