BDBM50618597 CHEMBL5434546

SMILES COc1ccc(cc1)-c1cc(ccn1)-c1ccn(Cc2ccc(cc2)C(=O)NO)n1

InChI Key InChIKey=LZDVZSHIAKMDMZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50618597   

TargetHistone deacetylase 1(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of C-terminal FLAG tagged recombinant human HDAC1 expressed in Sf9 cells using Ac-peptide as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of C-terminal FLAG-tagged human full length recombinant HDAC6 expressed in baculovirus expression system using Ac-peptide as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 10nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant HDAC2 (1 to 488 residues) expressed in Sf9 insect cells using Ac-peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 42nMAssay Description:Inhibition of C-terminal 6His-tagged human full length recombinant HDAC8 expressed in baculovirus expression system using Ac-peptide as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant LSD1 (unknown origin) using H3K4me2 as a substrate by amplex red/HRP based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of C-terminal His-tagged human HDAC5 catalytic domain (656 to 1122 residues) expressed in Sf9 insect cells using Ac-peptide as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged human recombinant MAO-B expressed in Sf9 cells preincubated for 15 mins followed by MAO substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50618597(CHEMBL5434546)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged human recombinant MAO-A expressed in Sf9 cells preincubated for 15 mins followed by MAO substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed