BDBM50618654 CHEMBL5393923

SMILES COc1cc(N2CCC(CC2)N2CC(C)(CO)C2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2P(C)(C)=O)n1

InChI Key InChIKey=NMSJKIAOJNJHER-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50618654   

TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618654BDBM50618654(CHEMBL5393923)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin) using TK as substrate incubated for 120 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618654BDBM50618654(CHEMBL5393923)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of EGFR del19/T790M/C797S triple mutant (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618654BDBM50618654(CHEMBL5393923)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of human recombinant EGFR L858R/T790M/C797S triple mutant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Southeast University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618654BDBM50618654(CHEMBL5393923)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using TK as substrate incubated for 120 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed