BDBM50618776 CHEMBL5428447

SMILES CCC(C)COc1sc(c2[C@H](O)C(F)(F)Cc12)S(C)(=O)=O

InChI Key InChIKey=HQXOCMVLSZMJFC-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50618776   

TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618776(CHEMBL5428447)
Affinity DataIC50: 1.99E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells transfected with HRE-luc2P assessed as decrease in luminescence incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618776(CHEMBL5428447)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells assessed as decrease in VEGF production incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618776(CHEMBL5428447)
Affinity DataKd:  5.00E+4nMAssay Description:Binding affinity to human recombinant HIF-2alpha (240 to 350 residues) assessed as as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed