BDBM50618782 CHEMBL5411078

SMILES CC(COc1sc(c2[C@H](O)C(F)(F)Cc12)S(C)(=O)=O)C(F)(F)F

InChI Key InChIKey=OBDBAEQKQSFFSR-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50618782   

TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618782(CHEMBL5411078)
Affinity DataKd:  3.80E+4nMAssay Description:Binding affinity to human recombinant HIF-2alpha (240 to 350 residues) assessed as as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618782(CHEMBL5411078)
Affinity DataIC50: 1.02E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells transfected with HRE-luc2P assessed as decrease in luminescence incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50618782(CHEMBL5411078)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells assessed as decrease in VEGF production incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed