BDBM50618789 CHEMBL5438635

SMILES CNc1cc(Nc2cccn([C@@H]3CC[C@@H](CC3)OC)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC

InChI Key InChIKey=RWTRNTPHYFRFAB-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50618789   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50618789(CHEMBL5438635)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50618789(CHEMBL5438635)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of TYK2 in human PBMC cells assessed as IL-12 induced phosphorylation of STAT4 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed