BDBM50618897 CHEMBL5394880

SMILES COc1cc(cc2CCN(CC(F)(F)F)C(=O)c12)-c1cnc(Nc2cc(nc(C)n2)N2CCN(C)CC2)s1

InChI Key InChIKey=WCLYSPWUHSZWOR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50618897   

TargetSerine/threonine-protein kinase SIK2(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of SIK2 (unknown origin) using AMARA as substrate buffer incubated for 60 mins followed by addition of ADP-Glo reagent further incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of SIK2 (unknown origin) using AMARA as substrate buffer incubated for 60 mins followed by addition of ADP-Glo reagent further incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of SIK3 (unknown origin) using AMARA as substrate buffer incubated for 60 mins followed by addition of ADP-Glo reagent further incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 17nMAssay Description:Inhibition of SIK3 (unknown origin) using AMARA as substrate buffer incubated for 60 mins followed by addition of ADP-Glo reagent further incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 33nMAssay Description:Inhibition of SIK1 (unknown origin) using AMARA as substrate buffer incubated for 60 mins followed by addition of ADP-Glo reagent further incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 140nMAssay Description:Inhibition of SIK1 (unknown origin) using AMARA as substrate buffer incubated for 60 mins followed by addition of ADP-Glo reagent further incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 4.89E+4nMAssay Description:Inhibition of human CYP2C19 by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C9 by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Insilico Medicine Shanghai

Curated by ChEMBL
LigandPNGBDBM50618897(CHEMBL5394880)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP1A2 by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed