BDBM50619817 CHEMBL5434792::US20240317663, Compound IIIa

SMILES C[C@@H]1[C@H](CCC\C1=C/C=C1/C[C@@H](O)C[C@H](O)C1=C)c1cccc(CCCC(C)(C)O)c1

InChI Key InChIKey=VHARJLXKHHHWHM-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50619817   

TargetVitamin D3 receptor(Human)
Kanagawa University

Curated by ChEMBL
LigandPNGBDBM50619817(US20240317663, Compound IIIa | CHEMBL5434792)
Affinity DataEC50:  7.40nMAssay Description:Agonist activity at Vitamin D receptor (unknown origin) assessed as increase in fluorescein labeled TRAP220/DRIP-2 coactivator peptide requirement by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVitamin D3 receptor(Human)
Kanagawa University

Curated by ChEMBL
LigandPNGBDBM50619817(US20240317663, Compound IIIa | CHEMBL5434792)
Affinity DataEC50:  7.40nMAssay Description:A VDR ligand binding domain tagged with GST (VDR-LBD(GST)), a fluorescein-TRAP220/DRIP-2-bound coactivator peptide (Fluorescein-peptide), LanthaScree...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetVitamin D3 receptor(Human)
Kanagawa University

Curated by ChEMBL
LigandPNGBDBM50619817(US20240317663, Compound IIIa | CHEMBL5434792)
Affinity DataEC50:  8.20nMAssay Description:Agonist activity at human Vitamin D receptor assessed as increase in gene transcriptional activity by luciferase reporter gene based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed