BDBM50620470 CHEMBL5404267

SMILES C[C@H]1CC2(CN1c1ccc(C#N)c(Cl)c1)CCN(CC2)c1ccc(cc1)C(=O)N1CCN(CC1)C1CN(C1)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1

InChI Key InChIKey=WBMJNGGUHCHFHY-UHFFFAOYSA-N

Data  9 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50620470   

TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataEC50:  0.600nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataEC50:  0.600nMAssay Description:Induction of androgen receptor degradation in human VCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using methionine as substrate preincubated for 5 mins followed by NADPH addition and measured after 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50620470(CHEMBL5404267)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed