BDBM50621126 CHEMBL5407312

SMILES ONC(=O)c1ccc(CN2CCC(CN[C@@H]3C[C@H]3c3ccccc3)CC2)cc1

InChI Key InChIKey=UMCMUHXVQOVKIH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50621126   

TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 4nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/19/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 31nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/19/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 110nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 110nMAssay Description:Inhibition of human HDAC6 expressed in baculovirus expression system in Sf9 cells using RHKKAc fluorogenic peptide as substrate and measured after 2 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 290nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant LSD1 using histone H3 1-21K4me as substrate incubated for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 540nMAssay Description:Inhibition of N-terminal human recombinant LSD1More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM50621126(CHEMBL5407312 | US20250162994, Example 11)
Affinity DataIC50: 5.40E+5nMAssay Description:Inhibition of human recombinant LSD1 by MALDI-TOF enzyme assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed